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Bleicher, K. Hit and lead generation: beyond high-throughput screening. Drug Discov. Butler, M. Antibiotics in the clinical pipeline at the end of King, A. Aspergillomarasmine A overcomes metallo-[bgr]-lactamase antibiotic resistance. Nature , — Mitchell, P.


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A perspective on protein microarrays. Sun, H. Recent advances in microarray technologies for proteomics.

Kiyonaka, S. Penicillin acylase catalysed synthesis of ampicillin in hydrophilic organic solvents. Palomo, J. Interfacial adsorption of lipases on very hydrophobic support octadecyl—Sepabeads : immobilization, hyperactivation and stabilization of the open form of lipases. B 19 , — Characterization of supports activated with divinyl sulfone as a tool to immobilize and stabilize enzymes via multipoint covalent attachment.

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Methods in Microarray Normalization

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Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip. Yang, Q. Composites of functional polymeric hydrogels and porous membranes. Ikeda, M. Supramolecular hydrogel-based protein and chemosensor array. Lab Chip 10 , — Lilly, J. Characterization of molecular transport in ultrathin hydrogel coatings for cellular immunoprotection. Biomacromolecules 16 , — Deng, X.

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Poly oligoethylene glycol methacrylate dip-coating: turning cellulose paper into a protein-repellent platform for biosensors. Shundo, A. Facile microcapsule fabrication by spray deposition of a supramolecular hydrogel.

Background

Chollet, B. Multiscale surface-attached hydrogel thin films with tailoredarchitecture. ACS Appl. These conclusions are based on analysis of 36 cDNA microarrays of 3, genes obtained in an experiment to search for changes in gene expression profiles during neuronal differentiation of cortical stem cells.


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Simulation studies confirm our findings. Biological processes depend on complex interactions between many genes and gene products. To understand the role of a single gene or gene product in this network, many different types of information, such as genome-wide knowledge of gene expression, will be needed. Microarray technology is a useful tool to understand gene regulation and interactions [ 1 - 3 ].


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